Endocrine Abstracts

IntroductionGraves’ Disease is an autoimmune syndrome that include hyperthyroidism, goiter, thyroid eye disease, and occasionally, a dermopathy called pretibial or localized myxedema. As each autoinmune ailment to develop in sufferers with genetic susceptibility after a certain environmental exposure (infection, stress…). COVID-19 can cause both pulmonary and systemic inflammation, potentially determining multi-organ dysfunction. Since the out...

IntroductionIn recent years, we have observed significant progress in cancer treatment associated with the development of immunotherapy. Nivolumab, an anti-PD-1 antibody, blocks the interaction between PD-1 and its ligands and inhibits the signaling pathway by preventing the tumor-derived PD-L1 from blocking T lymphocytes. In patients with metastatic melanoma, it is used either in monotherapy or in combination with other drugs. Immunotherapy is associate...

Acute pancreatitis (AP) is an inflammatory disorder of the pancreas, most commonly caused by gallstones and heavy alcohol consumption. The diagnosis is established with at least 2 of the following criteria: abdominal pain; increased serum lipase/amylase levels greater than 3 times the upper limit of normal value; or characteristic findings on contrast computed tomography (CT). Since the beginning of the severe acute respiratory syndrome coronavirus (SARS-CoV-2) pandemic, a few...

Selpercatinib is a receptor tyrosine kinase RET inhibitor for the treatment of cancers such as RET-mutant medullary thyroid cancer, demonstrating partial response and low incidence of serious adverse events. Vandetanib, a tyrosine kinase inhibitor, has shown promising results with an increase in progression-free survival and prolonged lifetime, but it causes adverse events such as hypertension, diarrhea, rash, or long QT interval. Most of them are can be even disabling for the...